eugenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4648 | 97-53-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A cinnamate derivative of the shikamate pathway found in CLOVE OIL and other PLANTS.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA CS | M0000728 | Allergens |
| CHEBI has role | CHEBI:27311 | essential oil component |
| CHEBI has role | CHEBI:33282 | bactericides |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35617 | flavouring agents |
| CHEBI has role | CHEBI:38623 | monoamine oxidase inhibitors |
| CHEBI has role | CHEBI:38634 | voltage-dependent sodium channel blockers |
| CHEBI has role | CHEBI:38867 | anaesthetic |
| CHEBI has role | CHEBI:48578 | free radical scavengers |
| CHEBI has role | CHEBI:50904 | alergeno |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
| CHEBI has role | CHEBI:68495 | Type I cell-death inducers |
| CHEBI has role | CHEBI:73240 | NF-kappaB inhibitors |
| CHEBI has role | CHEBI:85234 | human blood serum metabolites |
| CHEBI has role | CHEBI:139492 | sensitizers |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D012997 | Solvents |
| FDA PE | N0000175629 | Increased Histamine Release |
| FDA PE | N0000184306 | Cell-mediated Immunity |
| FDA EPC | N0000185508 | Standardized Chemical Allergen |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.12 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.96 | CHEMBL | |||||
| Arachidonate 5-lipoxygenase | Enzyme | IC50 | 4.58 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D04117 | KEGG_DRUG |
| 4019118 | VUID |
| N0000147369 | NUI |
| 4019118 | VANDF |
| C0015153 | UMLSCUI |
| CHEBI:4917 | CHEBI |
| EOL | PDB_CHEM_ID |
| CHEMBL42710 | ChEMBL_ID |
| DB09086 | DRUGBANK_ID |
| 2425 | IUPHAR_LIGAND_ID |
| 3T8H1794QW | UNII |
| 3314 | PUBCHEM_CID |
| 4186 | RXNORM |
| 12028 | MMSL |
| NOCODE | MMSL |
| 001106 | NDDF |
| 255924000 | SNOMEDCT_US |
| 411361005 | SNOMEDCT_US |
| D005054 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Dry Socket | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0699-0404 | PASTE | 0.04 g | DENTAL | UNAPPROVED DRUG OTHER | 9 sections |
| Red Cross Toothache | HUMAN OTC DRUG LABEL | 1 | 10742-0009 | LIQUID | 850 mg | TOPICAL | OTC monograph not final | 11 sections |
| Red Cross Toothache | HUMAN OTC DRUG LABEL | 1 | 10742-0009 | LIQUID | 850 mg | TOPICAL | OTC monograph not final | 11 sections |
| AnaDent Childrens Kanka Gel | HUMAN OTC DRUG LABEL | 1 | 27854-178 | GEL | 12 mg | DENTAL | OTC monograph not final | 11 sections |
| Dairy Allergen Mix | HUMAN OTC DRUG LABEL | 38 | 43742-1277 | LIQUID | 6 [hp_X] | ORAL | unapproved drug other | 9 sections |
| DenTek Eugenol | HUMAN OTC DRUG LABEL | 1 | 60630-566 | LIQUID | 850 mg | DENTAL | OTC monograph not final | 12 sections |
| Walgreens Natural Eugenol/Toothache Medicationwith cotton pellets and tweezers | HUMAN OTC DRUG LABEL | 1 | 60630-608 | LIQUID | 850 mg | DENTAL | OTC monograph not final | 9 sections |
| DenTek Eugenol | HUMAN OTC DRUG LABEL | 1 | 67659-400 | LIQUID | 850 mg | DENTAL | OTC monograph not final | 12 sections |
| DenTek Eugenol | HUMAN OTC DRUG LABEL | 1 | 67659-400 | LIQUID | 850 mg | DENTAL | OTC monograph not final | 12 sections |
| Walgreens Natural Eugenol/Toothache Medicationwith cotton pellets and tweezers | HUMAN OTC DRUG LABEL | 1 | 67659-405 | LIQUID | 850 mg | DENTAL | OTC monograph not final | 9 sections |
| Eugenol Toothache Medication | HUMAN OTC DRUG LABEL | 1 | 67659-415 | LIQUID | 850 mg | DENTAL | OTC monograph not final | 12 sections |
| Nuby Teething Gel | HUMAN OTC DRUG LABEL | 1 | 70797-230 | GEL | 13 mg | TOPICAL | OTC monograph not final | 8 sections |
| Nuby Teething Gel | HUMAN OTC DRUG LABEL | 1 | 71552-231 | GEL | 8 mg | TOPICAL | OTC monograph not final | 8 sections |
| PainONil | HUMAN OTC DRUG LABEL | 3 | 73417-758 | OINTMENT | 20 mg | TOPICAL | OTC monograph not final | 13 sections |
| TotalArthritis | HUMAN OTC DRUG LABEL | 3 | 73417-852 | OINTMENT | 40 mg | TOPICAL | OTC monograph not final | 13 sections |
| Marshall Toothache Drops | HUMAN OTC DRUG LABEL | 1 | 74094-002 | SOLUTION/ DROPS | 17 mg | DENTAL | OTC monograph not final | 9 sections |
| Marshall Toothache Drops | HUMAN OTC DRUG LABEL | 1 | 74094-002 | SOLUTION/ DROPS | 17 mg | DENTAL | OTC monograph not final | 9 sections |
| Anubis Barcelona | HUMAN OTC DRUG LABEL | 24 | 83021-553 | CREAM | 0.00 g | TOPICAL | OTC monograph final | 9 sections |
| DenTek Eugenol | HUMAN OTC DRUG LABEL | 1 | 83062-400 | LIQUID | 850 mg | DENTAL | OTC monograph not final | 12 sections |